Knowledge Item: CA-Medical Outcomes-40
Participant Satisfaction and Change in CD4 Counts, Viral Loads, Quality of Life, and Karnofsky Severity Ratings

This Knowledge Item also appears as Knowledge Item: CA-Quality of Life and Health-60 and Knowledge Item: CA-Program Satisfaction-23.

Knowledge Item: CA-Quality of Life and Health-39 shows that quality of life improves over time for the participants in the programs evaluated here.

This Knowledge Item shows that patients who have relatively the most improvement in their quality of life and whose clinicians rate their progress as most improving (or least deteriorating) rate the quality of their programs most highly. That is, patients who see improvements in themselves rate their programs most highly. Patients whose overall functioning is rated to be better by their clinicians rate their programs most highly. Program satisfaction is related to both patient-judged and clinician-judged improvement but not to changes in traditional medical indicators (CD4 count, viral load).

In this Knowledge Item, degree of change is operationalized as the linear slope parameter from the Hierarchical Linear Modeling (HLM) analyses, or the degree of sustained change across the entire treatment episode for the patient.


Knowledge Item: CA-Medical Outcomes-14 shows the the CD4 counts of patients in the programs evaluated here increase over time.


Knowledge Item: CA-Medical Outcomes-22 shows that the viral loads of patients in the programs evaluated here decrease over time.


Knowledge Item: CA-Medical Outcomes-18 shows that the Karnofsky Severity Ratings of patients in the programs evaluated here stay about the same over time.


This Knowledge Item shows that patients who have relatively the most improvement in their quality of life and whose clinicians rate their progress as most improving (or least deteriorating) rate the quality of their programs most highly.

Relationship Between Estimated Change in Quality of Life Over Time (from a Hierarchical Linear Model) and Patient Judgment About Quality of Services (statistically significant relationship; patients who improve most say their program has the highest quality)

All Patients Combined

By Type of Project

More Information:     Boxplot


Relationship Between Estimated Change in Clinical Karnofsky Severity Rating (from a Hierarchical Linear Model) and Patient Judgment About Quality of Services (statistically significant relationship; patients judged by the clinician to improve most say their program has the highest quality)

More Information:     Boxplot




The following charts shown the percentage of individual rating the services as fair/poor, good, very good, or excellent who improved.

Quality of Life


Karnofsky Severity Rating


CD4 Count


Viral Load

Patients or Clients?

Knowledge Item Citation: Huba, G. J., Melchior, L. A., Panter, A. T., and the HRSA/HAB SPNS Cooperative Agreement Steering Committee (1998-2001). Knowledge Item: CA-Medical Outcomes-40 from HRSA/HAB's SPNS Cooperative Agreements on Innovative Models of Care, The Measurement Group Knowledge Base on HIV/AIDS Care, Online at www.TheMeasurementGroup.com.

Last Updated: March 25, 2005; data through June 15, 1999; analyses conducted April - September 2000.




Knowledge Base Citation: The Knowledge Base and this Knowledge Item were designed and authored by G. J. Huba, Ph.D.; in collaboration with Lisa A. Melchior, Ph.D.; A. T. Panter, Ph.D.; and the staff of The Measurement Group. Cite this work as "Huba, G. J., Melchior, L. A., and Panter, A. T. (1998 - 2001). The Measurement Group Knowledge Base on HIV/AIDS Care. On the World Wide Web: http://www.TheMeasurementGroup.com."

Questions or Comments: Contact The Measurement Group.

Use of Knowledge Base Information: Acceptable Uses and Limitations.

Collaborators from Participating Projects: Cooperative Agreement Steering Committee 1999

Participating Projects: This Knowledge Base is based on the service delivery experiences of 27 Cooperative Agreement Projects on Innovative Models of HIV/AIDS Care. These projects and the Evaluation and Dissemination Center which produced this Knowledge Base were funded by the Health Resources and Services Administration (HRSA), HIV/AIDS Bureau (HAB) as Special Projects of National Significance (SPNS) between 1994 and 1999. Click the Model Programs button above for descriptions of the projects that contributed to this specific Knowledge Item, a list of key staff, and project grant numbers.

Why This Evaluation was Conducted: Editorial.

More Information: Design of this Knowledge Base.

Recommended Citation Format for Web Materials: American Psychological Association Publication Manual Section, Revised 2001.

Work on the Knowledge Base and the cross-cutting evaluation was supported in part by Grant Number 5 U90 HA 00030-05 from the Health Resources and Services Administration (HRSA), HIV/AIDS Bureau's (HAB) Special Projects of National Significance (SPNS). The contents of this Knowledge Base are solely the responsibility of The Measurement Group and do not necessarily represent the official views of HRSA or HRSA/HAB's Special Projects of National Significance nor may they represent the positions of the individual grantees whose projects are included in the cross-cutting evaluation.



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